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001271 - Trifluoroacetic acid

CAS Number 76-05-1 MDL Number MFCD00004169
Boiling Point 72.4° Melting Point -15.4°
Density 1.48 Purity 99%
Molecular Formula C2HF3O2 Molecular Weight 114.023
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250g £ 13.00 > 10
1kg £ 30.00 > 10
2.5kg £ 80.00 > 10
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Hazards and Precautions


Hazard Statements

H314: Causes severe skin burns and eye damage.
H332: Harmful if inhaled.
H412: Harmful to aquatic life with long lasting effects.

Precautionary Statements

P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear .
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.

Transport Hazards

UN Number 2699
Packing Group I
Shipping Name trifluoroacetic acid
Sub Class
Limited Qty Forbidden
Excepted Qty Inner(Not Permitted)  Outer(Not Permitted)
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Technical Information

Abbreviated as TFA. A precursor to many other fluorinated compounds such as trifluoroacetic anhydride and 2,2,2-trifluoroethanol.1 A reagent used in organic synthesis due to its volatility, solubility in organic solvents, and its strength as an acid.2 Popularly used as a strong acid in peptide synthesis and other organic synthesis to remove the t-butoxycarbonyl protecting group.An ion pairing agent in HPLC of organic compounds, particularly peptides and small proteins. A versatile solvent for NMR spectroscopy (for materials stable in acid)and a calibrant in mass spectrometry.4 Also used to produce trifluoroacetate salts that serve as precursors to ceramic materials such as YBa2Cu3O{7-x}.5

1.        Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH, 2005, 349.
2.        Encyclopedia of Reagents for Organic Synthesis. New York: J. Wiley & Sons, 2004.
3.        Int. J. Peptide Protein Res. 1978, 12, 258.
4.        Anal. Chem.198961, 2126.
5.        Supercond. Sci. Technol. 200316, 45.