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001272 - Trifluoroacetic anhydride

CAS Number 407-25-0 MDL Number MFCD00000416
Boiling Point 39.5-40°C Melting Point -65°C
Density 1.487 Purity 99%
Molecular Formula C4F6O3 Molecular Weight 210.031
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1kg £ 58.00 > 10
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Hazards and Precautions


Hazard Statements

EUH014: Reacts violently with water.
H314: Causes severe skin burns and eye damage.
H332: Harmful if inhaled.
H412: Harmful to aquatic life with long lasting effects.

Precautionary Statements

P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear .
P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see MSDS. on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local/regional/ national/international regulation.

Transport Hazards

UN Number 3265
Packing Group I
Shipping Name corrosive liquid, acidic, organic, n.o.s.
Sub Class
Limited Qty Forbidden
Excepted Qty Inner(Not Permitted)  Outer(Not Permitted)
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Technical Information

Abbreviated as TFAA. A reagent to introduce a trifluoromethyl group into an organic compounds. A trifluoroacetylating agent for protection of alcohols and amines, often used in trifluoacylation reactions like o-acylation, n-acylation or c-trifluoro-acylation.1 Applied as a catalyst in a smooth and efficient oxidation of isonitriles to isocyanates by sulfoxides,2 and for activating N,N'-di-Boc-substituted thiourea to thioacylate nucleophiles, such as amines, alcohols, thiols, sodium benzene­thiolate, and sodium malonates.3 Also used in synthesis of [1,2,4]Triazolo[1,5- a]pyridines,4 oxidation of alkyl aryl ketones to α-hydroxyalkyl aryl ketones in good yield 5 and catalyzing a highly enantioselective rearrangement of β-amino alcohols.6
1.        Tetrahedron 198743, 5583.
2.        Org. Lett. 201113, 2584.
3.        Synthesis 2010, 991.
4.        J. Org. Chem. 200570, 3761.
5.        Synthesis2008, 3205.
6.        J. Org. Chem.200772, 6556.